![]() ![]() To better identify sequencing reads derived from different DNA fragments, a technology called unique molecular identifier (UMI) has been developed. For example, cell-free DNA usually has a peak length of ~ 167 bp, which is much shorter than the peak length of normally fragmented genomic DNA. This possibility can be higher when the DNA fragments are shorter. However, for ultra-deep sequencing, it’s possible that two read pairs with same positions are derived from different original DNA fragments. Due to the nature that errors usually happen randomly, the inconsistent mismatches in the clustered read group can be removed to generate a consensus read. Then, the reads clustered together can be merged to be a single read. For low-depth paired-end NGS data, the read pairs of same start and end mapping positions can be treated as duplicated reads derived from a same original DNA fragment. Traditionally, we just mark the duplicated reads and remove them before downstream analysis. Especially for the high-depth data generated by sequencing low-input DNA, the duplication level can be much higher. Particularly, the library amplification using PCR technology can lead to particular sequences becoming overrepresented, and consequently cause some false positive mutations in the result of NGS data analysis.Īs a result of library amplification, NGS data can have many duplicates. However, the processes of making NGS library and sequencing are not error-free. To detect such low-frequency variants, we usually increase the sequencing depth (can be higher than 10,000x). Since the tumor-derived DNA is usually a small part of the total blood cell-free DNA, the mutant allele frequency (MAF) of a variant detected from ctDNA sequencing data can be very low (as low as 0.1%). Recently, circulating tumor DNA (ctDNA) sequencing has been recognized as a promising biomarker for cancer treatment and monitoring. From such deep sequencing data, somatic mutations can be detected to guide personalized targeted therapy or immunotherapy. High-depth next-generation sequencing (NGS) has been widely used for precision cancer diagnosis and treatment. To our best knowledge, gencore is the only duplicate removing tool that generates both informative HTML and JSON reports. Comparing to some new tools like UMI-Reducer and UMI-tools, gencore runs much faster, uses less memory, generates better consensus reads and provides simpler interfaces. ConclusionsĬomparing to the conventional tools like Picard and SAMtools, gencore greatly reduces the output data’s mapping mismatches, which are mostly caused by errors. The JSON format report contains all the statistical results, and is interpretable for downstream programs. The HTML format report contains many interactive figures plotting statistical coverage and duplication information. Gencore reports statistical results in both HTML and JSON formats. When unique molecular identifier (UMI) technology is applied, gencore can use them to identify the reads derived from same original DNA fragment. This error-suppressing feature makes gencore very suitable for the application of detecting ultra-low frequency mutations from deep sequencing data. While the consensus read is generated, the random errors introduced by library construction and sequencing can be removed. This tool clusters the mapped sequencing reads and merges reads in each cluster to generate one single consensus read. This paper presents an efficient tool gencore for duplicate removing and sequence error suppressing of NGS data. These unmet requirements drove us to develop an ultra-fast, simple, little-weighted but powerful tool for duplicate removing and sequence error suppressing, with features of handling UMIs and reporting informative results. Furthermore, existing tools rarely report rich statistical results, which are very important for quality control and downstream analysis. Some modern tools can work with UMIs, but are usually slow and use too much memory. Most existing duplicate removing tools cannot handle the UMI-integrated data. Recently, a new technology called unique molecular identifier (UMI) has been developed to better identify sequencing reads derived from different DNA fragments. However, as NGS technology gains more recognition in clinical application, researchers start to pay more attention to its sequencing errors, and prefer to remove these errors while performing deduplication operations. Removing duplicates might be considered as a well-resolved problem in next-generation sequencing (NGS) data processing domain. ![]()
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![]() Start program = "/etc/init.d/httpd start" with timeout 60 seconds Find and uncomment the process httpd line, this is a sample config: check process httpd with pidfile /var/run/httpd/httpd.pid The paths might be different in your system, make sure to check them before. Monit can monitor multiple processes and execute actions based on some conditions like CPU and memory usage. This is a sample capture of our server web interface: It will ask your for the username and password you have defined in the config file. You can test the web interface in a browser using the provided IP address or hostname (e.g. Start the monit service: sudo service monit start Use address 192.192.192.192 # Your IP address (private/public) for connections.Īllow 0.0.0.0/0.0.0.0 # What networks are allowed? Any network.Īllow admin:password # Set username and passwordĪllow # allow users of group 'monit' to connectĪllow readonly # allow users of group 'users' to connect readonlyĪdd monit to the system startup: sudo chkconfig monit on sudo vi /etc/nfįind the set httpd port line, uncomment and update the configuration, here is a sample configuration: set httpd port 2812 and Install Monit sudo yum install monit Monit Web Interfaceįirst open the configuration file, you can also use the nano editor. The steps to install the monitoring tool Monit under CentOS 6 are similar to other service like Apache, you can also follow this tutorial or this one (Monit part) if you are under CentOS 7 and this might help for Ubuntu. Yes, Apache and MySQL are running in the same server with the current configuration. This would manifest when bots like googlebot started scanning intensively the server. ![]() This happened as the number of web services and websites in the server increased. Thus, MySQL was eventually killed as well as the ElasticSearch service. The problemĮssentially, the Apache server was consuming most of the RAM leaving little for other processes. It also explains how to avoid the Apache server from exhausting the memory. ![]() ![]() This blog post describes how to set up a monitoring tool ( Monit) under CentOS 6 to monitor processes and to restart them when necessary. Even after a memory increase to a total of 3+ GB, the problem persisted. The MySQL server at the SysCrunch server was always being killed, the reason was due to lack of resources (RAM). ![]() ![]() Questions? Posted something that's missing? Ask a mod. Promotional posts for products and services are prohitted unless pre-approved by the moderators.These are okay in comments, when relevant. Links to deals are okay but do not post affiliate links or your for-profit content as new links.This step by step guide will walk through the steps needed to use the USB, smartphone and Bluetooth channels to connect a wide range of devices including tablets, smartphones and computers. This is called ‘unity gain’ and is a good place to start. Learn how to connect callers and online guests with the RDECaster Pro. Push up the fader for Channel 1 to the fifth line from the top. Switch on the power outlet at the wall, then press the red power button on the back of your RDECaster Pro to power it up. While I understand a pat on the back and a word of encouragement is a good thing, it's extraneous to the purpose of the subreddit. This is for Channel 1 on the RDECaster Pro. Please no kudos threads where you reach a milestone, thank the academy and your agent or another gratuitous congratulatory verbiage as these look suspiciously like a self-promotional post in an attempt to bypass Rule 3. ![]() ![]() However, if you're looking for feedback, use the Weekly Episode Threads. This is a compressor that is applied to the combined output of your RDECaster Pro, including each mic input, the smartphone, USB and Bluetooth channels, and the sound pads.
![]() ![]() ![]() This reliable encryption Mac software stores information in the form of cards and uses industry-standard. They were assessed on attributes including application, texture, look and feel of skin during use and coverage level, culminating in 546 data points that were meticulously evaluated to create this list of the best under-eye concealers you can buy for dark circles, wrinkles, dry skin and more. Hide and Encrypt Files and Passwords on Your Mac. ![]() In order to find the best concealers, our analysts in the Good Housekeeping Institute Beauty Lab partnered with professional makeup artists to test 26 best-selling formulas, from drugstore concealers to high-end picks. 125in Cord Hider - Yecaye One-Cord Channel Cable Concealer - Cord Cover Wall - Easy Install Cable Management System for Max 2 Small Wires, Cable Raceway Home Office, 8X L15.7in W0.59in H0.4in, White 4. Dark circles or eye bags usually gives a dark, purplish cast to your skin tone. And here’s a little tip we learnt from Hourglass’ Global Director of Artistry, Marc Reagan. Since the skin under the eyes is among the thinnest on the body, it tends to be dry and fragile, so it requires gentle concealer formulas that won't irritate, yet provide enough coverage for issues like dark circles and can spread easily over fine lines. 153in Cord Hider Wall, Wire Hiders for 3 Cords, Cord Cover for 2 Thick Extension Cables, Paintable Cable Cover to Hide Cords Wall Mounted TV, Cord Concealer, 9X L17in X W0.95in X 0.47in, White. We’ve collated ten of our favourite ones that can brighten and hide imperfections so you immediately look more radiant and awake. Sports Supplements also third-party certified as NSF Certified for Sport or Banned Substances Control Group (BSCG) Drug Free. But not all coverups are created equal: Some are better for blemishes and dark spots, some for redness and others specifically for the under-eye area. 0 Comments Feminine Care, Adult Care & Diapers - fragrance free and chlorine free.Also, cruelty free and/or not tested on animals. This will help break up the blood clots and will improve circulation in the area. Once your neck is warm enough, use your fingers to rub the hickey in a circle, from the inside of the hickey outwards. Concealer is one of the most effective makeup products you can use, instantly helping even out your skin's tone whether you're wearing foundation or not. If you just got your hickey, apply ice and begin massaging the area. ![]() ![]() ![]() Adding Custom HTML WidgetsĪdding custom HTML (or code sandbox) to a tag should be migrated from Mattertag.injectHTML to Tag.registerSandbox and Tag.attach. Tags now support multiple media (or attachments) per tag. Providing media in Mattertag.add or Mattertag.editBillboard should be migrated to use Tag.registerAttachment and Tag.attach. Eventually, this will also be the case for Pointer.editTexture. Instead, Asset.registerTexture should be used. The Tag namespace does not have a registerIcon function like the Mattertag namespace does. We have moved to a unified texture registry for icons and other visuals. Mattertag.registerIcon should be migrated from Mattertag.registerIcon to Asset.registerTexture. A brief summary of the major changes Existing Functionality However, any future Tag capabilities will be added to the Tag namespace. After the full release, the Mattertag namespace will be considered deprecated, but still functional. The Mattertag namespace should continue to work whether or not the application is using Tags 2.0. Rather than shoehorning a new interface on top of an existing namespace, Tags 2.0 (Tags) seek to provide the foundation for more powerful tag-based capabilities in the future. However, the Mattertag interface and architecture doesn’t directly support future extended capabilities, such as hosted content. Traditional Mattertags allow for the viewing of embedded content and information about particular locations within a Matterport space. Some are now more robust and require more than a single step to use. Most operations that are available in the Mattertag namespace have an equivalent operation in the Tag namespace. Note it's redundant to find the commit hash for HEAD.Tags (2.0), is the successor to Mattertags. if `git describe -contains HEAD 2&>1 > /dev/null` then Note using 2> /dev/null to suppress error output.īut it's safer to instead completely ignore the output and check the exit value. NEEDS_TAG=`git describe -contains HEAD 2> /dev/null` You can use -n to look for a non-empty string and flip the logic. Your program will always tag because -z looks for a null string, it will still fire on "". $ git tag -points-at HEADĪs will git log -decorate $ git log -decorateĬommit 8ce1cfebecda68ba42226d0e6cd5dbebba76ae0b (HEAD -> master, tag: foo, tag: bar) Git tag -points-at HEAD will show all tags that point at the current commit. $ git describe -abbrev=0 -tagsįatal: No names found, cannot describe anything. Multiple tags can point to a single commit, but git describe -abbrev=0 -tags will only show one. You can see I've fetched the latest tags and it shows v0.0.8, but still shows v0.0.7 as the current tag of the repository. #only tag if no tag already (would be better if the git describe command above could have a silent option)Įcho "Tagged with $NEW_TAG (Ignoring fatal:cannot describe - this means commit is untagged) " NEEDS_TAG=`git describe -contains $GIT_COMMIT` ![]() #get current hash and see if it already has a tag Git commit -allow-empty -m "Updating $VERSION to $NEW_TAG" #get number parts and increase last one by 1 This is the source code of the script: $ cat archive/tag_git_repo.sh Tagged with v0.0.8 (Ignoring fatal:cannot describe - this means commit is untagged) It's supposed to update from the latest tag v0.0.8 to v0.0.7./archive/tag_git_repo.sh Git failing to update tag with fatal: tag 'v0.0.8' already exists ![]() ![]() In addition, it requires a 32-bit and 64-bit setup. With vary compatibility with all types of devices, the app has special compatibility with all types of Windows-Windows 10, Windows 8.1, Windows 7, Windows Vista, and Windows XP are mainly operating systems to run the app very smoothly and reliably. It is developed by Wondershare software and belongs to office tools. The Wondershare PDFelement available for Windows 32-bit operating system of a laptop and PC, presented for all software users as a free trial for a specific period, free download with potential restrictions. Wondershare PDFelement 6 is a well presented app with stacks of useful features that allows modifications to text, graphics, watermarks, digital signatures. ![]() Use PDFelement to read or edit the inserted PDF document. Click the 'Insert'>'Object' button to select the PDF document to insert. Beyond that, there are premium subscription plans that can be paid either. Attach sticky notes for necessary information, use audio or video recordings for sending one thousand or above words, etc. How to Insert a PDF into a Word Document. PDFelement is offered with a free trial that provides complete access to the application’s features for a limited time. You can highlight the text in different ways like strikethrough, underline, and yellow highlighting. The program format is fully edited, even if you want to review the document, use annotation options, digital forms, and signatures. PDF files can be useful, but they can also be a hassle if you need to edit them or modify. Similarly, ignore the boring method of old manual data entry use the latest OCR technology for converting piles of documents into the archive and analysis-friendly Office files. Amazing software that allows you to modify and edit PDF files. ![]() Wondershare PDFelement Features Simple Exportingįast exporting of multiple identical forms into an exclusive Excel sheet via auto-fill form option without using JavaScript. As the full feature version of PDFElement Standard, PDFElement Pro aims to provide everything you might need when working with PDF documents. ![]() ![]() ![]() ![]() This solution meets the needs of many different industries and offers robust features to withstand change in the long run: Kronos Workforce Central is an easy-to-use workforce management interface that allows employees to access self-service portals with one click and gives managers increased visibility into data insights and employee dashboards. Key Features and Benefits Kronos Workforce Central Each of these systems holds a different purpose within your organization but can be easily integrated with other applications and systems, like Workday, to make the most out of your ERP system. Kronos, now part of the Ultimate Kronos Group (UKG) gives users the opportunity to choose from three main workforce management systems: Kronos Workforce Central, Kronos Workforce Ready, and Kronos Dimensions. Kronos Workforce Management offers multiple different tools that help manage employee resources and optimize business processes with a single technology interface. Even better, its diverse functionality and customizable applications allow for it to be used in companies of many different sizes, industries, and locations with the same focus – people. Workday understands that people are the heart of all organizations, and they should be the focus of enterprise software. Consistent functionality across global workforces.Regular software updates and upgrades to optimize business processes.High-quality applications, modules, and integration tools.Seamless integration with internal and external systems and applications.More engaged and empowered employees and managers.Reduced costs from a single-system approach.Increased visibility into important data and insights.With Workday’s advanced capabilities and integration features, users are able to manage their data securely in one system, offer real-time insights, and allow for seamless integration between internal Workday applications and external systems, like Kronos. Workday offers easy-to-use applications and modules that help organizations optimize their HR software and business processes, including payroll, recruiting, benefits administration, talent and performance management, learning, compensation, data conversion, and more. The Workday Enterprise Management Cloud is an entirely cloud-based Software as a Service (SaaS) platform that allows users to keep track of their organizational solutions for human capital management (HCM), financial management, enterprise resource planning (ERP), and spend management. This article will cover the key features of each system and how Workday Kronos integrations can help you achieve end-to-end human capital management (HCM) that benefits your entire workforce. So if your solutions need a little integration TLC, you’ve come to the right place. ![]() Tools like Workday and Kronos can do wonders for your business, but treating them as separate machines you turn to when they’re needed will never be as effective as integrating them together. If this sounds like a familiar problem, you’re not alone. Each tool serves a purpose and fulfills a specific need, but before you know it, all of those technologies you brought on to save time can start leading to more manual work. ![]() Home > Insights > Kronos Workday Integration: How to Optimize Your HCM SystemsĪs your business and employee base grows, it’s common to add more software as needed to manage your “people” operations. ![]() ![]() ![]() Later that year, in October, the release of Ice Age Scrat’s Nutty Adventure for Outright Games on PlayStation 4, Xbox One, Switch and PC occurred.Ī teaser trailer for Doctor Who: The Edge of Reality was released in October 2020 by Maze Theory, with a release date for 2021. In March 2019 it was announced that Just Add Water would be partnering with Rebellion to release Sniper Elite VR, a standalone VR title for the Sniper Elite series that would be released for PlayStation VR, Oculus VR and Steam VR. In 2018 the team grew to 25 strong and began work on titles for Outright Games and Rebellion. In 2017 Just Add Water completed work on Micro Machines World Series for Codemasters and moved into their new office in Leeds City Centre, and sought to expand their team to begin work on several new projects. This work was focused on porting various projects from PC to console, and assisting development of titles. ![]() ĭuring this time the company also revisited their title Gravity Crash, by creating a PlayStation VITA version titled Gravity Crash Ultra, which was released in August 2014.įrom 2014 through to 2017 Just Add Water worked with new partners and clients, such as Paradox Interactive, Rising Star Games, Bossa Studios & Mike Bithell. In April 2015, Oddworld Inhabitants announced that an all-new remake of Oddworld: Abe's Exoddus is in the planning stages and more information about the project will be announced later. ![]() Oddworld Inhabitants have also stated that 'Squeek's Oddysee' is in pre-production phases, with Just Add Water as the developer. They have announced that they will complete Oddworld: Hand of Odd, which is a real-time strategy online game which was halted in the early 2000s, and it shall be released as a free-to-play title. One of the next new instalments is a 2D HD remake of the Abe's Oddysee game, Oddworld: New 'n' Tasty! came out in the Summer of 2014 (beating its own 12 month sales prediction within 2 months of release) and had a public showing of pre-alpha footage at Eurogamer Expo 2012. The title did well to beat its own 12 month sales prediction within 2 months of release. Oddworld: New 'n' Tasty launched in July 2014 on PS4 to critical acclaim, with other platforms arriving in the months following. ![]() Towards the end of development on Stranger’s Wrath HD, the team moved over to start development on what would become Oddworld: New 'n' Tasty for PS4, Xbox One, PS3, VITA, PC, Mac and Linux. They have released an HD Remake of Oddworld: Munch's Oddysee HD for the PlayStation Network which was released on 19 December in Europe and on Christmas Eve 2012 in North America. Just Add Water released Oddworld: Stranger's Wrath HD for the PlayStation Network on 21 December in Europe and 28 December in North America. Both Oddworld: Munch's Oddysee and Oddworld: Stranger's Wrath made their debut on Windows PC with updates including Steamworks, which integrated new features including stats and Steam Achievements.in 2010 for PC, then a year later for PS3, and then PlayStation VITA in 2012. Oddworld: Stranger’s Wrath HD, a conversion of the 2005 original, was released on 3 September 2010, updating Oddworld: Stranger's Wrath in HD with enhanced 720p visuals, more detailed character models, remastered dialogue, PlayStation Move Support and "additional bonus material." Ī collection containing all four original games called the Oddbox, for Steam service was released on 20 December 2010. On 16 July 2010, Just Add Water announced they would start work on multiple Oddworld projects after signing a far-reaching contract with Lorne Lanning’s Oddworld Inhabitants to develop properties in the Oddworld franchise, a move Gilray describes as a "turning point" for the studio. PS3 and PSP versions released in 2009/2010. The studio worked as a sub-contractor on a number of titles before moving onto its first unique project, Sony-published retro shooter Gravity Crash, in 2008. was founded in 2006 by British career developer Stewart Gilray. They have teamed up with Oddworld Inhabitants, to recreate the series in high definition as well as working on new installments in the series. Founded by Stewart Gilray in 2006, Just Add Water has worked on different titles for the PlayStation 3 and PC, notably the Oddworld series. Just Add Water (Development) Limited is an independent video game developer based in Leeds, UK. ![]() |
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